Prognostic and predictive value of the combination of TOP2A and HER2 in node-negative tumors 2 cm or smaller (T1N0) breast cancer.

CONCLUSION: Patients with both HER2+ and high expression level of TOP2A protein predicts poor prognosis in T1N0 breast cancer patients. Patients with double positive for TOP2A protein and HER2 may benefit from anthracycline-based regimens. PMID: 32780321 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32780321?dopt=Abstract

Source: Breast Cancer - August 10, 2020 Category: Cancer & Oncology Authors: Zhong W, Yang Y, Zhang A, Lin W, Liang G, Ling Y, Zhong J, Yong J, Liu Z, Tian Z, Lin Q, Luo Q, Li Y, Gong C Tags: Breast Cancer Source Type: research