Unlike dengue virus, the conserved 14–23 residues in N-terminal region of Zika virus capsid is not involved in lipid interactions

Publication date: Available online 9 August 2020Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Kumar Udit Saumya, Deepak Kumar, Prateek Kumar, Rajanish Giri
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research

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Zika virus (ZIKV) is an emerging arbovirus belonging to the genus Flavivirus, family Flaviviridae, which includes other viruses relevant to public health, such as dengue (DENV), yellow fever (YFV) and West Nile (WNV) viruses. Although ZIKV infection in humans is often characterized as a self-limiting disease 1,2, infections during pregnancy can lead to fetal malformations and neurodevelopment abnormalities 3 –5.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Conclusions: From all the circulating mediators measured, we detected differences of IL-10, TNF- α, and CCL2/MCP-1 between arbovirus groups. We hypothesize that CXC10/IP-10, CCL2/MCP-1, and MIF in the CHIKV-infected group could regulate the CHIKV viral load, while CXC10/IP-10, CCL2/MCP-1, and TNF-α in DENV/ZIKV, and CHIKV/ZIKV groups, could regulate ZIKV viral load.Intervirology
Source: Intervirology - Category: Virology Source Type: research
Abstract Infections by flaviviruses, such as Dengue, West Nile, Yellow Fever and Zika viruses, represent a growing risk for global health. There are vaccines only for few flaviviruses while no effective treatments are available. Flaviviruses share epidemiological, structural, and ecologic features and often different viruses can co-infect the same host. Therefore, the identification of broad-spectrum inhibitors is highly desirable either for known flaviviruses or for viruses that likely will emerge in the future. Strategies targeting both virus and host factors have been pursued to identify broad-spectrum antiflav...
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research
Aedes spp. are responsible for the transmission of many arboviruses, which contribute to rising human morbidity and mortality worldwide. The Aedes aegypti mosquito is a main vector for chikungunya, dengue and yel...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
es SG Abstract Zika and Dengue viruses present considerable immunological cross-reactivity, resulting in a troublesome serodiagnosis due to occurrence of false positive results. Due to Brazil's wide variety of circulating flaviviruses we aimed to access the use of in house serological tests adapted by National Reference Laboratory for Arboviruses in Brazil and evaluate commercial tests available. We evaluated in house IgM ELISAs for the individual detection of anti-ZIKV, -DENV, and -YFV IgM, against a panel of samples positive for dengue, zika, yellow fever, Rocio, Ilheus, Saint Louis encephalitis, West Nile and c...
Source: Journal of Virological Methods - Category: Virology Authors: Tags: J Virol Methods Source Type: research
by Tyler M. Sharp, Talia M. Quandelacy, Laura E. Adams, Jomil Torres Aponte, Matthew J. Lozier, Kyle Ryff, Mitchelle Flores, Aidsa Rivera, Gilberto A. Santiago, Jorge L. Mu ñoz-Jordán, Luisa I. Alvarado, Vanessa Rivera-Amill, Myriam Garcia-Negrón, Stephen H. Waterman, Gabriela Paz-Bailey, Michael A. Johansson, Brenda Rivera-Garcia BackgroundAfter Zika virus (ZIKV) emerged in the Americas, laboratory-based surveillance for arboviral diseases in Puerto Rico was adapted to include ZIKV disease. Methods and findingsSuspected cases of arboviral disease reported to Puerto Rico Department of Health were teste...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
DISCUSSION: The paper discusses the impact of human activities on landscape and its effects on mosquito populations, focusing on the segregation of different known vector species and their proximity to human altered environments. Most of these species are known arbovirus vectors and knowledge of their distribution are key elements that health authorities should take into account when planning arbovirus surveillance and vector control activities. PMID: 32971068 [PubMed - as supplied by publisher]
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
ConclusionAs we have seen in this review, many important developments in our basic understanding of GCX structure, function and role in diseases have been described since the 2007 paper. The future is wide open for continued GCX research.
Source: Cardiovascular Engineering and Technology - Category: Cardiology Source Type: research
Abstract Viruses were identified from male anthropophilic mosquitoes from Mato Grosso (MT) State, Midwest Brazil from February 2017 to January 2018. Mosquitoes tested included Aedes (Stegomyia) aegypti (1139 males; 84 pools), Culex quinquefasciatus (9426 males; 179 pools), Culex sp. (3 males; 3 pools) and Psorophora albigenu (1 male; 1 pool) collected from four cities of MT. Pools were subjected to viral RNA extraction followed by RT-PCRs specific for ten flaviviruses, five alphaviruses and Simbu serogroup of orthobunyaviruses. Positive pools were passaged three times in VERO cells (alphavirus and orthobunyavirus)...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
Background: Chikungunya (CHIKV), dengue and zika share similar symptoms, which makes a clinical diagnosis complex in regions where the three arboviruses co-circulate. We evaluated the accuracy of the World Health Organization's (WHO) CHIKV case definition against the gold standard of laboratory diagnosis, in individuals with suspicion of arboviral illness seeking care in an urban emergency department (ED) in Rio de Janeiro, Brazil, from January –June 2018.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0635 Source Type: research
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