SARS-CoV-2 Causes a Specific Dysfunction of the Kidney Proximal Tubule

Coronavirus disease 2019 (COVID-19) is commonly associated with kidney damage, and the angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 is highly expressed in the proximal tubule cells. Whether patients with COVID-19 present specific manifestations of proximal tubule dysfunction remains unknown. To test this, we examined a cohort of 49 patients requiring hospitalization in a large academic hospital in Brussels, Belgium. There was evidence of proximal tubule dysfunction in a subset of patients with COVID-19, as attested by low-molecular-weight proteinuria (70-80%), neutral aminoaciduria (46%), and defective handling of uric acid (46%) or phosphate (19%).

Source: Kidney International - August 9, 2020 Category: Urology & Nephrology Authors: Alexis Werion, Leila Belkhir, Marie Perrot, Gregory Schmit, Selda Aydin, Zhiyong Chen, Andrea Penaloza, Julien De Greef, Halil Yildiz, Lucie Pothen, Jean Cyr Yombi, Joseph Dewulf, Anais Scohy, Ludovic G érard, Xavier Wittebole, Pierre-François Laterre, Tags: clinical investigation Source Type: research