Structure-Activity Relationship of Anti-malarial Allylpyrocatechol Isolated from Piper betle.

In this study, we verified that 1 showed in vivo anti-malarial activity through not only intraperitoneal (i.p.) but also peroral (p.o.) administration. Additionally, some analogs of 1 were synthesized and the structure-activity relationship was analyzed to disclose the crucial sub-structures for the potent activity.
PMID: 32741921 [PubMed - in process]

Source: Chemical and Pharmaceutical Bulletin - August 5, 2020 Category: Drugs & Pharmacology Authors: Tamura S, Miyoshi A, Kawano T, Horii T, Itagaki S, Murakami N Tags: Chem Pharm Bull (Tokyo) Source Type: research