O-GlcNAcylation of Mef2c regulates myoblast differentiation.
In this study, we showed that hyper-O-GlcNAcylation reduced the expression of myogenin, a transcription factor critical for terminal muscle development, in C2C12 myoblasts differentiation by O-GlcNAcylation on Thr9 of myocyte-specific enhancer factor 2c. Furthermore, we showed that O-GlcNAcylation on Mef2c inhibited its DNA binding affinity to myogenin promoter. Taken together, we demonstrated that hyper-O-GlcNAcylation attenuates skeletal muscle differentiation by increased O-GlcNAcylation on Mef2c, which downregulates its DNA binding affinity.
PMID: 32736694 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Kim HB, Seo HG, Son S, Choi H, Kim BG, Kweon TH, Kim S, Pai J, Shin I, Yang WH, Cho JW Tags: Biochem Biophys Res Commun Source Type: research
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