IL-1 α modulates IFN-γ induced production of CXCL9/MIG during Herpes Simplex Virus type-1 corneal infection.

CONCLUSIONS: Our data provides evidence demonstrating the potential for expression patterns of MIG and IP-10 to be modulated by IL-1α, during the inflammatory response to HSV-1 corneal infection. Both corneal cells and neutrophils contribute to the production of T cell recruiting chemokines. However, IL-1α has the potential to up-regulate MIG production by corneal cells while down-regulating MIG production by neutrophils.
PMID: 32730721 [PubMed - as supplied by publisher]

Source: Current Eye Research - July 29, 2020 Category: Opthalmology Authors: Armstrong S, Arroyo M, Decker-Pulice K, Lane M, Mckinney M, Molesworth-Kenyon SJ Tags: Curr Eye Res Source Type: research