Antifibrotic Effects of Bezafibrate and Pioglitazone Against Thioacetamide-Induced Liver Fibrosis in Albino Rats.

Antifibrotic Effects of Bezafibrate and Pioglitazone Against Thioacetamide-Induced Liver Fibrosis in Albino Rats. Can J Physiol Pharmacol. 2020 Jul 28;: Authors: Ibrahim S, Mohamed MZ, El-Tahway N, Abdelrahman AM Abstract Activation of hepatic stellate cells is a central event in hepatic fibrogenesis that offers multiple potential sites for therapeutic interventions. Peroxisome proliferators activated receptors are implicated in liver fibrosis. We aimed to evaluate the effect of bezafibrate and pioglitazone on a thioacetamide (TAA) rat model of liver fibrosis and to clarify the possible underlying mechanisms. Rats received intraperitoneal injections of TAA for 6 weeks. Daily oral treatments with bezafibrate or pioglitazone were started with the first day of TAA-intoxication. Serum liver function tests, hepatic malondialdehyde (MDA), total nitrite and nitrate (NOx), superoxide dismutase and hepatic histopathology were assessed to evaluate hepatic damage. Alpha smooth muscle actin (αSMA) and tissue inhibitor metalloproteinase-1 (TIMP-1) and caspase-3 were also assessed. TAA group experienced significant deterioration of liver functions, increased oxidative stress and increased liver tissue NOx. Administration of bezafibrate or pioglitazone resulted in significant improvement of all liver functions and reduced oxidative stress in hepatic tissues. Only administration of bezafibrate significantly reduced NOx levels. Liver tissues from TA...
Source: Canadian Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Can J Physiol Pharmacol Source Type: research