Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination [Neuroscience]

CCN3 is a matricellular protein that promotes oligodendrocyte progenitor cell differentiation and myelination in vitro and ex vivo. CCN3 is therefore a candidate of interest in central nervous system (CNS) myelination and remyelination, and we sought to investigate the expression and role of CCN3 during these processes. We found CCN3...

Source: Proceedings of the National Academy of Sciences - July 27, 2020 Category: Science Authors: Nira de la Vega Gallardo, Rosana Penalva, Marie Dittmer, Michelle Naughton, John Falconer, Jill Moffat, Alerie G. de la Fuente, Jose R. Hombrebueno, Zhiyong Lin, Bernard Perbal, Rebecca J. Ingram, Emma Evergren, Denise C. Fitzgerald Tags: Biological Sciences Source Type: research