Quantifying the contribution of Fc-mediated effector functions to the antiviral activity of anti-HIV-1 IgG1 antibodies in vivo [Microbiology]
In combating viral infections, the Fab portion of an antibody could mediate virus neutralization, whereas Fc engagement of Fc-γ receptors (FcγRs) could mediate an array of effector functions. Evidence abounds that effector functions are important in controlling infections by influenza, Ebola, or HIV-1 in animal models. However, the relative contribution...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Pengfei Wang, Mili R. Gajjar, Jian Yu, Neal N. Padte, Agegnehu Gettie, James L. Blanchard, Kasi Russell-Lodrigue, Laura E. Liao, Alan S. Perelson, Yaoxing Huang, David D. Ho Tags: Biological Sciences Source Type: research