Power and Sample Size Calculations for Genetic Association Studies in the Presence of Genetic Model Misspecification

Conclusions: Understanding the impact of model misspecification can aid in study design and developing analysis plans that maximize power to detect a range of true underlying genetic effects. In particular, these calculations help identify when a multiple degree of freedom test or other robust test of association may be advantageous.Hum Hered
Source: Human Heredity - Category: Genetics & Stem Cells Source Type: research