Synthesis and Antioxidant Activity Evaluation of Trolox Derivatives

To find potent antioxidants, 16 novel Trolox derivatives were designed and synthesized via a reduction and esterification reaction. The chemical structures were characterized by NMR and MS. Trolox derivatives were employed to explore the potential structure –antioxidant activity relationships using three different assays. The results revealed that some of the synthesized compounds exhibited stronger antioxidant activities than L-ascorbic acid and Trolox, which suggests such compounds warrant further study.
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research