HDAC6/HNF4 α loop mediated by miR-1 promotes bile acids-induced gastric intestinal metaplasia

ConclusionsOur findings show that the HDAC6/HNF4 α loop regulated by miR-1 plays a critical role in gastric IM. Blocking the activation of this loop could be a potential approach to preventing BA-induced gastric IM or even gastric cancer (GC).
Source: Gastric Cancer - Category: Gastroenterology Source Type: research