Lung cancer and intraocular metastasis in gestation: Clinical experiences of a rare case

We here report an extremely rare case of a 31 ‐year‐old non‐smoking pregnant female who was diagnosed as lung adenocarcinoma with multiple metastasis including choroid metastasis. Whole exon sequencing was performed but no appropriate therapeutic target has been identified. Lung cancer in pregnancy combined with intraocular metastasis rarely occurs and has a poor prognosis. Here, we report an extremely rare case of a 31 ‐year‐old non‐smoking pregnant female who was diagnosed with lung adenocarcinoma with multiple metastasis including choroidal metastasis. Whole exon sequencing was performed but no appropriate therapeutic target was identified. The patient received standard pemetrexed plus carboplatin for firs t‐line treatment after delivery. Ophthalmic treatment including transpupillary thermotherapy and intravitreal ranibizumab injections were administered and the patient responded very well to treatment. Her visual acuity was restored, indicating systemic therapy combined with ophthalmic treatment wa s an appropriate choice of therapy.Key pointsSignificant findings of the studyThe case reported here of a pregnant female diagnosed with lung cancer with choroidal metastasis highlights the aggressive characteristics of the disease.What this study addsSystemic therapy in combination with ocular therapy is an appropriate choice of treatment.

Source: Thoracic Cancer - July 20, 2020 Category: Cancer & Oncology Authors: Lin Lin, Jing Sun, Jie Wang Tags: CASE REPORT Source Type: research