Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism [Immunology and Inflammation]

Differences between female and male immunity may contribute to variations in response to infections and predisposition to autoimmunity. We previously reported that neutrophils from reproductive-age males are more immature and less activated than their female counterparts. To further characterize the mechanisms that drive differential neutrophil phenotypes, we performed RNA sequencing...

Source: Proceedings of the National Academy of Sciences - July 13, 2020 Category: Science Authors: Sarthak Gupta, Shuichiro Nakabo, Luz P. Blanco, Liam J. O’Neil, Gustaf Wigerblad, Rishi R. Goel, Pragnesh Mistry, Kan Jiang, Carmelo Carmona–Rivera, Diana W. Chan, Xinghao Wang, Hege L. Pedersen, Manasi Gadkari, Katherine N. Howe, Faiza Naz, Tags: Biological Sciences Source Type: research