TWiV 638: Do, there is no try

Daniel Griffin provides a clinical update on COVID-19, then Viviana Simon joins to review serological assays developed at Mt. Sinai for SARS-CoV-2 infection, tracking the outbreak in NYC, and listener questions. Click arrow to playDownload TWiV 638 (99 MB .mp3, 164 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees Send your virology questions and […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology antibodies COVID-19 pandemic PCR SARS-CoV-2 serological assay viral virus viruses Source Type: blogs

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Little is known about the mental health consequences of severe COVID-19 illness because it is caused by a new coronavirus. Previous outbreaks caused by other coronaviruses (severe acute respiratory syndrome, SARS, and Middle East respiratory syndrome, MERS) may provide insights into ongoing problems after recovery from severe illness. Researchers looked at reports of psychiatric problems during SARS and MERS outbreaks and compared this to early data from the COVID-19 pandemic. Delirium (sudden confusion) was common while patients were in hospital with any of the coronavirus infections (SARS, MERS or COVID-19). Later, once ...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
It is a frightening time to live in the United States. COVID-19, a novel disease as ruthless as it is seemingly random, is picking us off by the thousands; even many of those who “recover” may never truly be the same again. The pandemic has exposed the gulf between what this country promises for its citizens and what it actually delivers. And as the U.S. barrels toward Election Day, the outbreak is sure to complicate the voting process, with potentially disastrous results. For a short time in the spring, it appeared the U.S. was getting a grip on its outbreak. Hard-hit states like New York successfully flattene...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized COVID-19 UnitedWeRise20Disaster Source Type: news
Authors: Heitzman J Abstract Human confrontation with such a stressor as the COVID-19 pandemic outbreak, caused by SARS-CoV-2 virus, manifested in severe acute respiratory distress, results also in the decrease of fitness and mental resistance on an unprecedented scale and with difficult to estimate consequences [1]. More important than the intensity of the disorder is its prevalence. When we compare our current knowledge of the impact of the pandemic on the development of mental disorders with the findings of research on acute stress disorder (ASD) and posttraumatic stress disorder (PTSD) over the last 40 years, i...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
Authors: Xiong R, Zhang L, Li S, Sun Y, Ding M, Wang Y, Zhao Y, Wu Y, Shang W, Jiang X, Shan J, Shen Z, Tong Y, Xu L, Chen Y, Liu Y, Zou G, Lavillete D, Zhao Z, Wang R, Zhu L, Xiao G, Lan K, Li H, Xu K Abstract Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide, such as the on-going outbreak of the novel coronavirus SARS-CoV-2. Herein, we identified two potent inhibitors of human DHODH, S312 and S416, with favorable drug-likeness and pharmacokinetic profiles, which all showed broad-spectrum antiviral effects against various RNA viruses, including influenza A virus, Zika virus,...
Source: Protein and Cell - Category: Cytology Tags: Protein Cell Source Type: research
On March 11, 2020, the World Health Organization declared the SARS-CoV-2 outbreak to be a pandemic which has sent all countries in a frenzy. We cannot be callous about treatment of non-COVID-19-related patients. The Wardha district of Maharashtra is a decl...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
We report 10 candidates with optimal binding features to the active site of the protease for further consideration as potential drugs to treat patients infected with the emerging COVID-19 disease. PMID: 32773989 [PubMed]
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
Coronavirus disease 2019 outbreak has a growing impact on global health; vertical transmission of severe acute respiratory syndrome coronavirus 2 infection is still controversial. In this article, we describe a case of vertical transmission of severe acute respiratory syndrome coronavirus 2 in a newborn with respiratory and gastrointestinal symptoms.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Instructive Cases Source Type: research
Coronaviruses (CoVs) are a group of viruses from the family Coronaviridae that can infect humans and animals, causing mild to severe diseases. The ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a global threat, urging the development of new therapeutic strategies. Here we present a selection of relevant compounds that have been described from 2005 until now as having in vitro and/or in vivo antiviral activities against human and/or animal CoVs. We also present compounds that have reached clinical trials as well as further discussing the potentiality of other molecules for applic...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Abstract Since its recent onset, the COVID-19 pandemic has significantly altered the daily lives of millions around the world. One area particularly affected is our diets, with food supply chain disruptions, media coverage of food safety issues and restaurant closures all influencing consumer dietary behavior. Given this situation, we pose a timely question - what is the impact of the current pandemic on longer-term meat consumption patterns? This issue is pertinent given accumulating evidence that overconsumption of meat, particularly red meat, is associated with negative environmental and health outcomes. Here, ...
Source: Public Health Nutrition - Category: International Medicine & Public Health Authors: Tags: Public Health Nutr Source Type: research
The novel coronavirus disease 2019 (COVID-19), a viral outbreak caused by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), began in Wuhan, China in December 2019 and was declared a Public Health Emergency of International Concern on the 30th January 2020 (WHO, 2020b). Seven months into COVID-19 pandemic, the number of cumulative cases remain steadily on the increase. As at 3rd August 2020, 17,660,523 cases had been detected, with 680,894 deaths globally. Africa contributes 4.5% of global morbidity and 2.0% of fatalities (WHO, 2020a).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Perspective Source Type: research
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