Mechanistic studies on the drug metabolism and toxicity originating from cytochromes P450.
Mechanistic studies on the drug metabolism and toxicity originating from cytochromes P450. Drug Metab Rev. 2020 Jul 09;:1-29 Authors: Jaladanki CK, Gahlawat A, Rathod G, Sandhu H, Jahan K, Bharatam PV Abstract Cytochromes P450 are oxidizing enzymes; a few families of cytochromes P450 are implicated in drug metabolism. These enzymatic reactions involve many processes including (i) prodrug to drug conversion, (ii) easy excretion of drug, (iii) generation of reactive metabolites, many of which cause toxicity. In this review, the fundamental biochemical mechanisms associated with the conversion of drugs into the useful or toxic metabolites have been discussed. The mechanisms can be established with the help of many experimental methods like mass spectral analysis, NMR and in vitro analysis etc. Computational methods provide detailed atomic level information, which is generally not available from experimental studies. Thus, the in silico efforts in elucidating the molecular mechanisms are complementary to the known experimental methods and are often clearer (especially in providing 3D information about the metabolites and their reactions). Quantum chemical methods and molecular docking become especially very useful. This review includes five case studies, which explain how the atomic level details were obtained to explore the reaction mechanisms of drug metabolism by cytochromes P450. PMID: 32645272 [PubMed - as supplied by publisher]
Publication date: Available online 4 August 2020Source: Results in PhysicsAuthor(s): Fredy L. Dubeibe, Euaggelos E. Zotos, Wei Chen
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This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Priscilla M Matos, Robert Stockman This review article explores the synthesis of the organosulfur(VI) species named sulfonimidates, focusing on their synthesis from both sulfur(IV) and sulfur(VI) species, and investigates their recent resurgeance in interest as... The content of this RSS Feed (c) The Royal Society of Chemistry
Authors: Lord K, De León DD Abstract Hypoglycemia remains a significant cause of morbidity in infants and children. Up to 50% of children with hypoglycemic disorders suffer from neurodevelopmental deficits, as a consequence of delays in the diagnosis and inadequate treatment. Recent advances in the field have resulted in new therapies and improved outcomes. To review these advances and have a dialogue regarding controversies in the field, the Fourth International Hyperinsulinism Symposium, sponsored by the Children's Hospital of Philadelphia was held in Philadelphia, Pennsylvania on September 5-6, 2019. The ...
Authors: Zoledziewska M Abstract Hypoglycaemia is the most common metabolic health complication in newborns. Persistent and severe hypoglycaemia in a neonate is correlated with morbidity and could represent an early clinical manifestation of an endocrine or metabolic, genetically determined disorder. Besides this, the most common reason for neonatal hypoglycaemia is the inmature liver storage of glucose seen in preterms or children born intrauterine growth retarded. The genetic determination of hypoglycaemia is gene- and allele- heterogeneous, and thus complex to diagnose. Nevertheless its contribution to brain dam...
Authors: Sharma S, Sharma P Abstract BACKGROUND: Hypertension is one of the leading morbid factors in adults but often a less noticeable concern in childhood age group. Young population is now more vulnerable to lifestyle disorders leading to early chronic diseases if not addressed due to presence of ignorance and inadequate assessment. To label hypertension in pediatric age group, blood pressure should be ≥ 95th percentile for age, height and sex in small children. OBJECTIVE: Purpose of review is to unfurl the knowledge for monitoring and management of hypertension in children. We emphasize the need to spre...
CONCLUSION: It was observed that patients who preserved gonadal tissues were able to enter puberty spontaneously. PMID: 32741155 [PubMed - in process]
CONCLUSION: These reference intervals may help to increase the diagnostic power for the assessment of endocrine disorders during the first year of life. PMID: 32741154 [PubMed - in process]