Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine.

CONCLUSIONS: RT cell lines and xenografts are highly sensitive to HHT, at least partially due to their low expression of BCL2L1. HHT may have therapeutic potential against RTs.
PMID: 32631955 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - July 5, 2020 Category: Cancer & Oncology Authors: Howard TP, Oberlick EM, Rees MG, Arnoff TE, Pham MN, Brenan L, DoCarmo M, Hong AL, Kugener G, Chou HC, Drosos Y, Mathias KM, Ramos P, Seashore-Ludlow B, Giacomelli AO, Wang X, Freeman BB, Blankenship K, Hoffman L, Tiv HL, Gokhale PC, Johannessen CM, Stewa Tags: Clin Cancer Res Source Type: research