Stem Cell Strategies Get Compassionate Use in COVID-19 Stem Cell Strategies Get Compassionate Use in COVID-19

Mesenchymal stem cells are being reimagined to tackle COVID-19-associated acute respiratory distress syndrome.Medscape Medical News
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Infectious Diseases News Source Type: news

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AbstractThe Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was identified in December 2019. The symptoms include fever, cough, dyspnea, early symptom of sputum, and acute respiratory distress syndrome (ARDS). Mesenchymal stem cell (MSC) therapy is the immediate treatment used for patients with severe cases of COVID-19. Herein, we describe two confirmed cases of COVID-19 in Wuhan to explore the role of MSC in the treatment of COVID-19. MSC transplantation increases the immune indicators (including CD4 and lymphocytes) and decreases the inflammation indicators (interleukin-6 and C-reactive protein). High-flow nasal...
Source: Frontiers of Medicine - Category: General Medicine Source Type: research
Conclusions: On the whole, the children were previously healthy and are more than 1 year old. Respiratory symptoms were the leading cause of PICU admission, making respiratory support the principal therapy. Patients requiring mechanical ventilation showed deterioration on the first day of admission. These children seemed to require close monitoring, and multicenter studies are necessary.
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Online Brief Reports Source Type: research
Conditions:   Covid19;   Corona Virus Infection;   SARS-CoV Infection;   ARDS;   Coronavirus Interventions:   Biological: Umbilical Cord Lining Stem Cells (ULSC);   Other: Placebo (carrier control) Sponsor:   Restem, LLC. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Rationale: The COVID-19 cases increased very fast in January and February 2020. The mortality among critically ill patients, especially the elder ones, is relatively high. Considering many patients died of severe inflammation response, it is urgent to develop effective therapeutic strategies for these patients. The human umbilical cord mesenchymal stem cells (hUCMSCs) have shown good capabilities to modulate the immune response and repair the injured tissue. Therefore, investigating the potential of hUCMSCs to the treatment of COVID-19 critically ill patients is necessary. Patient concerns: A 65-year-old woman felt fa...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Abstract The world has witnessed unimaginable damage from the coronavirus disease-19 (COVID-19) pandemic. Because the pandemic is growing rapidly, it is important to consider diverse treatment options to effectively treat people worldwide. Sincethe immune system is at the hub of the infection, it is essential to regulate the dynamic balance in order to prevent the overexaggerated immune responses that subsequently result in multiorgan damage. The useof stem cells as treatment options has gained tremendous momentum in the past decade. The revolutionary measures in science have brought to the world mesenchymal stem ...
Source: BMB Reports - Category: Biochemistry Authors: Tags: BMB Rep Source Type: research
Publication date: Available online 30 July 2020Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Ghada Elgohary
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research
The purpose of this guideline is to maximise the safety of patients who need haemopoietic stem cell transplantation and make the best use of NHS resources, while protecting staff from infection. On 29 July 2020, we amended recommendations on advice and testing for COVID-19 for patients and donors, and removed recommendations on deferring treatment for some patients to reflect changes in the risk of infection and the capacity in services. See 2 External 0 0 0 update information false https://www.nice.org.uk/guidance/ng164/chapter/Update-information true false%> for details.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Conditions:   COVID-19;   Acute Respiratory Distress Syndrome;   Corona Virus Infection Interventions:   Biological: UCMSCs;   Other: Placebo Sponsor:   Joshua M Hare Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Skin's unusual response to stretching is finally explained, and the latest in a huge effort to map DNA.In this episode:01:06 Stretching skinFor decades it’s been known that stretching skin causes more skin to grow, but the reasons why have been a mystery. Now, researchers have uncovered a mechanism to explain the phenomenon. Research Article: Aragona et al.; News and Views: Stretch exercises for stem cells expand the skin07:49 CoronapodWe discuss how the coronavirus pandemic has affected scientific meetings and how the learned societies that organise them are adapting. How scientific conferences will survive the...
Source: Nature Podcast - Category: Science Authors: Source Type: podcasts
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