Body weight, CYP2C19 , and P2Y12 receptor polymorphisms relate to clopidogrel resistance in a cohort of Chinese ischemic stroke patients with aspirin intolerance

ConclusionsThe patients with high body weight, theCYP2C19 phenotypes, andP2Y12 receptor (52 G>T) variant alleles are at risk of CR during clopidogrel treatment in Chinese IS patients with aspirin intolerance. The higher body weight and relevant polymorphisms may help to predict CR in Chinese IS patients with aspirin intolerance.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research