Alpha Frequency rTMS Modulates Theta Lagged Nonlinear Connectivity in Dorsal Attention Network.

This study is an investigation of the behavioral and network effects of alpha and theta repetitive transcranial magnetic stimulation (rTMS) over RDLPFC. 20 healthy participants were randomly assigned to two groups of theta (n = 11, f = 10 Hz) and alpha (n = 9, f = 6 Hz) rTMS. Electroencephalogram (EEG) was recorded before and after each session while resting and performing tasks. Current source density (CSD) and functional connectivity (FC) in DAN and default mode network (DMN) and their correlations with rapid visual information processing task (RVIP) scores were conducted by eLORETA. Alpha frequency rTMS resulted in significant changes in RVIP scores. Active theta rTMS caused an increase in CSD in Postcentral gyrus and active alpha rTMS resulted in significant CSD changed in inferior parietal lobule (IPL). Active alpha rTMS resulted in the modulation of theta lagged nonlinear connectivity. FC changes were observed in DAN and DMN. Positive correlations were observed between DAN regions and RVIP scores in the alpha rTMS group. Increased activity in theta frequency band in left aPFC and left DLPFC correlated positively with higher total hits in RVIP. This study showed for the first time that theta and alpha frequency rTMS is able to modulate FC in DAN and DMN in a way that results in better performance in a sustained attention task.
PMID: 32619694 [PubMed - as supplied by publisher]

Source: Brain Research Bulletin - June 29, 2020 Category: Neurology Authors: Kazemi R, Rostami R, Dehghan S, Nasiri Z, Lotfollahzadeh S, Hadipour AL, Khomami S, Ishii R, Ikeda S Tags: Brain Res Bull Source Type: research