A Frailty Screening Tool for Patients undergoing Orthotopic Heart Transplant
Publication date: Available online 3 July 2020Source: The Annals of Thoracic SurgeryAuthor(s): Laura Seese, Sameer Hirji, Ibrahim Sultan, Thomas Gleason, Arman Kilic
Authors: Ghali MGZ, Stewart R, Ghali GZ, Blitzer W Abstract Facile identification of cardiac allograft vasculopathy (CAV), extensively prevalently identifiable across recipients of cardiac explanted allografts, has proven challenging using non-invasive modalities exclusively. We consequently sought to evaluate diagnostic precision and accuracy of two-dimensional speckle tracking echocardiography (2D-STE) to the end of detecting international society heart &lung transplantation stage III graft vasculopathy (ISHLT-CAV3) in individuals having received cardiac allografts by the meritorious pre-mortem scripted or ve...
Publication date: October 2020Source: IJC Heart &Vasculature, Volume 30Author(s): R.O. Ohiomoba, Q.R. Youmans, P.W. Akanyirige, A.U. Ezema, A.S. Anderson, A. Bryant, K. Jackson, E. Mandieka, D.T. Pham, Y. Raza, J.D. Rich, C.W. Yancy, I.S. Okwuosa
IN THE MODERN ERA, a multitude of mechanical devices are used to temporize organ perfusion and hemodynamics in patients with heart failure, and thus “bridge” these patients to recovery, transplant, or a durable assist device. However, with increasing frequency of their placement, the rate of malposition has also increased, sometimes with serious consequences.1 Modifications to either insertion or device design also have been developed becaus e of a desire to increase mobility, reduce cost, and optimize comfort.
Patients with preformed antibodies against Human Leukocyte Antigens (HLA) wait longer for a transplant, have higher mortality on the waitlist and worse overall prognosis [1, 2]. There however remains some doubt regarding the impact of elevated pre-transplant panel reactive antibody activity (PRA) on post-transplant risk of rejection and survival [3, 4]. Historically, a PRA value greater than 25% was shown to be associated with decreased long-term survival based on data from both single center and larger UNOS/OPTN registry analysis [1, 3].
We describe the case of an 18‐year‐old male patient, affected by DMD and in a wheelchair from the age of 11. He progressively developed dilated cardiomyopathy, and in 2016, at the age of 14 years, he underwent HeartWare LVAD implantation, as destination therapy, without post‐operative complications. He has been followed up for 47 consecutive months; and 30 months after LVAD implantation, he developed an infection of the exit site, treated by antibiotics and surgical toilette. Following this event, on the basis of patient's good general conditions and willingness, we started to consider heart transplant as a...
Conclusions: POLVAD-MEV paracorporeal pulsatile pumps present a safe option for long-term circulatory support in a selected group of patients. Therapy requires pump exchange but enables survival while awaiting a heart transplant. PMID: 32728373 [PubMed]
Conclusions: DCM and ICM are considered the most prevalent underlying diseases in heart transplant candidates. Ejection fraction reached normal ranges following transplant, which provides good quality of life. Low incidence of severe acute rejection demonstrates the effectiveness of our immunosuppressive therapy. In the cases of increased rejection, the patient's immunosuppressive regimen was re-assessed accordingly. PMID: 32728361 [PubMed]
Dr. Alin Gragossian gets it. Wearing a mask, social distancing, frequently washing your hands, using a sanitizing gel or wipe on everything you touch -- all that gets old, fast.
Objectives: To evaluate the value of cardiac power output index (CPOi) in predicting severe primary graft dysfunction (PGD) after heart transplantation (defined as mechanical circulatory support [MCS] and/or mortality
In conclusion, this study has demonstrated the cardiac differentiation potential of [Glu2]-dianthin G (1)-treated rat bone marrow MSCs in vitro both at the gene and at the protein levels. Transplantation of pre-differentiated MSCs into the infarcted myocardium may result in the efficient regeneration of cardiac cells and restoration of normal cardiac function. PMID: 32737770 [PubMed - as supplied by publisher]