Implementing PRED Subroutine of NONMEM for Versatile Pharmacokinetic Analysis using Fast Inversion of Laplace Transform (FILT).

In this study, we focus on extending the modeling functions of NONMEM, a standard software for PK and population pharmacokinetic (PPK) analyses, by adding the Fast Inversion of Laplace Transform (FILT) method, one of the representative numerical inverse Laplace transform methods. We implemented PREDFILT, a specialized PRED subroutine, which functions as an internal model unit in NONMEM to enable versatile FILT analysis with second-order precision. The calculation results of the compartment models and a dispersion model are in good agreement with the ordinary analytical solutions and theoretical values. Therefore, PREDFILT ensures enhanced flexibility in PK or PPK analyses under NONMEM environments.
PMID: 32611991 [PubMed - as supplied by publisher]

Source: Chemical and Pharmaceutical Bulletin - June 30, 2020 Category: Drugs & Pharmacology Authors: Jin R, Hisaka A Tags: Chem Pharm Bull (Tokyo) Source Type: research