Secondary analysis of RTOG 0247 demonstrates favorable OS rates for rectal cancer patients

Locally advanced rectal cancer patients who receive preoperative radiation therapy with either irinotecan plus capecitabine or oxaliplatin plus capecitabine have a four-year overall survival rate of 85 percent and 75 percent, respectively, according to a study.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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CONCLUSIONS: IMRT is a safe and effective means to achieve local control in patients with unresectable or incompletely resected differentiated thyroid cancer. Concurrent doxorubicin was not associated with worse toxicity and should be considered given its potential to improve local control and OS. PMID: 30105947 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Radiofrequency ablation (RFA) has been used successfully in Japan to treat post-surgery recurrence of malignant pleural mesothelioma, according to a case study published recently by the Society of Thoracic Surgeons. Although RFA has been utilized for several years to treat various thoracic lesions, the study authors believe this is the first time it worked effectively with mesothelioma cancer cells. “It shows promising efficacy,” the authors wrote. “Radiofrequency should be considered an option for treating recurrence of MPM [malignant pleural mesothelioma].” RFA is a minimally invasive medical proc...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Abstract PURPOSE: The occurrence of upper extremity lymphedema after regional nodal irradiation (RNI) for breast cancer treatment varies significantly based on patient and treatment factors. The relationship between the radiation therapy (RT) field design and lymphedema risk is not well-characterized. The present study sought to correlate the variations in RT field design with lymphedema outcomes. METHODS AND MATERIALS: Women with stage II-IV breast cancer receiving RNI after breast surgery that included sentinel lymph node biopsy or axillary dissection were identified. Their arm circumference was measured be...
Source: Ann Oncol - Category: Cancer & Oncology Authors: Tags: Int J Radiat Oncol Biol Phys Source Type: research
Authors: Reid E, Suneja G, Ambinder RF, Ard K, Baiocchi R, Barta SK, Carchman E, Cohen A, Gupta N, Johung KL, Klopp A, LaCasce AS, Lin C, Makarova-Rusher OV, Mehta A, Menon MP, Morgan D, Nathwani N, Noy A, Palella F, Ratner L, Rizza S, Rudek MA, Taylor J, Tomlinson B, Wang CJ, Dwyer MA, Freedman-Cass DA Abstract People living with HIV (PLWH) are diagnosed with cancer at an increased rate over the general population and generally have a higher mortality due to delayed diagnoses, advanced cancer stage, comorbidities, immunosuppression, and cancer treatment disparities. Lack of guidelines and provider education has le...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Conditions:   Brain Diseases;   Brain Cancer Interventions:   Device: Wiersma Head Stabilizer;   Device: AlignRT system Sponsor:   University of Chicago Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: Surgery in SCCNV gives an excellent prognosis and minimized the need for radiotherapy. PMID: 30098234 [PubMed - as supplied by publisher]
Source: Rhinology - Category: ENT & OMF Tags: Rhinology Source Type: research
ConclusionsTreatment with EBRT or IB does not appear to impair sexual function in women with gynecologic cancer. Age less than 50, concurrent chemotherapy, and cervical cancer may place women with gynecologic cancer at higher risk for decreased sexual function following radiation.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
(NIH/National Cancer Institute) An interim analysis of data from a randomized clinical trial of patients with human papillomavirus (HPV)-positive oropharyngeal cancer found that treatment with radiation therapy and cetuximab is associated with worse overall and progression-free survival compared to the current standard treatment with radiation and cisplatin. The trial was designed to see if cetuximab with radiation would be less toxic than cisplatin with radiation without compromising survival for patients with the disease.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
DNA-damaging chemotherapy and radiation therapy are integrated into the treatment paradigm of the majority of cancer patients. Recently, immunotherapy that targets the immunosuppressive interaction between programmed death 1 (PD-1) and its ligand PD-L1 has been approved for malignancies including non–small cell lung cancer, melanoma, and head and neck squamous cell carcinoma. ATR is a DNA damage–signaling kinase activated at damaged replication forks, and ATR kinase inhibitors potentiate the cytotoxicity of DNA-damaging chemotherapies. We show here that the ATR kinase inhibitor AZD6738 combines with conformal r...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
ConclusionPreoperative CRT with CF and elective lymph node irradiation showed an acceptable toxicity and promising activity especially in ESCC.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
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