Prevalence and characteristics of PIK3CA mutation in mismatch repair-deficient colorectal cancer

Conclusions: The molecular pathogenesis is different between dMMR and pMMR tumors with PIK3CA mutation in CRC. PIK3CA mutation may act as a clonally dominant truncal mutation in dMMR CRC. Thus, combination of PIK3CA mutation and MMR status might determine a specific group of CRC to select treatment or elevate prognosis.

Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Weihua Li, Tian Qiu, Lin Dong, Fanshuang Zhang, Lei Guo, Jianming Ying Tags: Research Paper Source Type: research