Genetic code expansion strategies for vaccine development.

Genetic code expansion strategies for vaccine development. Chembiochem. 2020 Jun 30;: Authors: Fok JA, Mayer C Abstract By providing long-term protection against infectious diseases vaccinations have significantly reduced death and morbidity world-wide. In the 21 st century, (bio)technological advances have paved the way for developing prophylactic vaccines that are safer and more effective as well as enabled the use of vaccines as therapeutics to treat human diseases. Here, we provide a focused review on the utility of genetic code expansion as an emerging tool for the development of vaccines. Specifically, we discuss how the incorporation of immunogenic non-canonical amino acids can aid in eliciting immune responses against adverse self-proteins and highlight the potential of an expanded genetic code for the construction of replication-incompetent viruses. We close the review by discussing future prospects and remaining challenges for the application of these approaches in the development of both prophylactic and therapeutic vaccines in the near future. PMID: 32608153 [PubMed - as supplied by publisher]
Source: Chembiochem - Category: Biochemistry Authors: Tags: Chembiochem Source Type: research