Reduced Platelet miR-223 Induction in Kawasaki Disease Leads To Severe Coronary Artery Pathology Through a miR-223/PDGFR β Vascular Smooth Muscle Cell Axis.

Conclusions: Platelet-derived miR-223 (through PDGFRβ inhibition) promotes VSMC differentia-tion and resolution of KD induced vascular injury. Lack of miR-223 induction leads to severe coro-nary pathology characterized by VSMC dedifferentiation and medial damage. Detection of platelet-derived miR-223 in KD patients (at the time of diagnosis) may identify patients at greatest risk of coronary artery pathology. Moreover, targeting platelet miR-223 or VSMC PDGFRβ represents po-tential therapeutic strategies to alleviate coronary pathology in KD.
PMID: 32597702 [PubMed - as supplied by publisher]

Source: Circulation Research - June 28, 2020 Category: Cardiology Authors: Zhang Y, Wang Y, Zhang L, Xia L, Zheng MH, Zeng Z, Liu YY, Yarovinsky TO, Ostriker AC, Fan X, Weng K, Su M, Huang P, Martin KA, Hwa J, Tang WH Tags: Circ Res Source Type: research