Metronomic Chemotherapy for Patients with Metastatic Breast Cancer: Review of Effectiveness and Potential Use During Pandemics

The conventional use of chemotherapy for all types of cancer is based on the concept of “Dose Intensity”, which means periodic delivery of the drugs at an established maximum tolerated dose (MTD), usually every 3-4 weeks. This mode of delivery aims at targeting dividing cancer cells and may affect actively dividing normal cells thus leading to the reported multiple adverse events s econdary to chemotherapy. Delivering the chemotherapy drugs at a certain interval is essential to allow the recovery of normal cells thus limiting adverse effects; however, this may allow cancer cells to regrow and acquire resistance [1].

Source: Cancer Treatment Reviews - June 28, 2020 Category: Cancer & Oncology Authors: Johny E. Fares, Paul El Tomb, Lana E. Khalil, Rula W. Atwani, Hiba A. Moukadem, Ahmad Awada, Nagi S. El Saghir Tags: Anti-tumour Treatment Source Type: research