Chemical constituents of the Vietnamese marine sponge Gelliodes sp. and their cytotoxic activities.

Chemical constituents of the Vietnamese marine sponge Gelliodes sp. and their cytotoxic activities. Chem Biodivers. 2020 Jun 27;: Authors: Ki DW, Kodama T, El-Desoky AH, Wong CP, Nguyen HM, Minh K, Thai QM, Nu LHT, Morita H Abstract A new decenoic acid derivative, gelliodesinic acid ( 1 ), and a natural new indole alkaloid ( 2 ), together with three known furanoterpenoids ( 3 - 5 ) and two known indole alkaloids ( 6 - 7 ), were isolated from the MeOH extract of the marine sponge Gelliodes sp. collected in Vietnam. The chemical structures of 1 - 7 were determined by analyses of 1D- and 2D-NMR and MS data and by comparisons of the data with those reported in the literature. The cytotoxicity assay against HeLa, MCF-7, and A549 cancer cell lines revealed that the known furanoterpenes 3 - 5 exhibited cytotoxic activities, with IC 50 values ranging from 23.6 to 75.5 μM, against the three cell lines, and that 6 showed cytotoxicity with an IC 50 value of 89.2 μM against A549 cancer cell line. PMID: 32592287 [PubMed - as supplied by publisher]
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research