By targeting TRAF6, miR-140-3p inhibits TGF- β1-induced human osteosarcoma epithelial-to-mesenchymal transition, migration, and invasion.

CONCLUSION: These results demonstrate miR-140-3p to function as a tumor inhibitor of human OS cells by decreasing TRAF6 expression. miR-140-3p and TRAF6 may be valuable and novel biomarkers for diagnosis and treatment of OS.
PMID: 32562135 [PubMed - as supplied by publisher]

Source: Biotechnology Letters - June 18, 2020 Category: Biotechnology Authors: Guo Q, Zhang N, Liu S, Pang Z, Chen Z Tags: Biotechnol Lett Source Type: research