GBA variation and susceptibility to multiple system atrophy

Genetic variants in the glucocerebrosidase (GBA) gene have been previously associated with susceptibility to synucleinopathies. The risk is well-established in Lewy body disease but is not as confirmed for multiple system atrophy (MSA). We aim to evaluate associations between exonic variants in GBA and risk of neuropathologically-confirmed multiple system atrophy (MSA).

Source: Parkinsonism and Related Disorders - June 20, 2020 Category: Neurology Authors: Anna I. Wernick, Ronald L. Walton, Shunsuke Koga, Alexandra I. Soto-Beasley, Michael G. Heckman, Ziv Gan-Or, Yingxue Ren, Rosa Rademakers, Ryan J. Uitti, Zbigniew K. Wszolek, William P. Cheshire, Dennis W. Dickson, Owen A. Ross Source Type: research