The importance of optimal ROIs delineation for FBPA-PET before BNCT.

The importance of optimal ROIs delineation for FBPA-PET before BNCT. Appl Radiat Isot. 2020 Sep;163:109219 Authors: Lo YW, Lee JC, Hu YS, Li CY, Chen YL, Lin CS, Huang WS, Lin KH, Chen YW Abstract One of the eligible criteria for patients to receive boron neutron capture therapy (BNCT) is based on the tumour-to-normal ratio (T/N) measured by FBPA-PET. However, there is no standard protocol for normal region-of-interested delineation. With comparison of contralateral cerebrum, our study revealed the consistency (p < 0.05) and high feasibility using the cerebellum as an alternative normal tissue baseline because of its homogeneous uptake. Following RECIST version 1.1, the standard-operating-procedure (SOP) for the BNCT fulfilled the expected tumour response and tumour shrinkage rate (p < 0.05). Our modified procedure can provide more precise information for BNCT within a reasonable time. PMID: 32561058 [PubMed - as supplied by publisher]
Source: Applied Radiation and Isotopes - Category: Radiology Authors: Tags: Appl Radiat Isot Source Type: research