4-hydroxynonenal and oxidative stress in several organelles and its damaging effects on cell functions.

4-hydroxynonenal and oxidative stress in several organelles and its damaging effects on cell functions. J Physiol Pharmacol. 2020 Feb;71(1): Authors: Gallo G, Sprovierio P, Martino G Abstract This review aims to describe the action sites of the oxidative stress products for 4-hydroxy-2E-nonenal, on subcellular fractions of eukaryotic cells from several tissues. Described also are; the detoxification mechanisms from derivatives of 4-hydroxy-2E-nonenal. All dangerous compounds for subcellular fractions are metabolites of a respiratory chain that can give stable products of oxidative compounds and are intermediates of other oxidation reaction chains. Finally, the balancing among the illustrated processes to identify the relative oxidative power of several metabolic chains useful to make evident subcellular damages or detoxification processes is discussed. PMID: 32554842 [PubMed - in process]
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research