Molecular characterization of prostate cancer in Middle Eastern population highlights differences with Western populations with prognostic implication.

CONCLUSION: This study documents significant differences in key molecular events in PCA in Middle Eastern population compared to Western populations that could explain differences in PCA incidence, progression and prognostication. ERG, PTEN and SPINK1 genomic alteration occur less frequently and the enrichment of ERG for PTEN loss is not observed. Additionally, patients with combined PTEN loss/ERG positive are at highest risk for BCR vs North American Caucasian population where PTEN loss alone seems to be associated with the worst clinical outcome. The data presented here further support differences in clonal evolution between Middle Eastern and Western population in relation to PCA and add further insight to understanding PCA molecular pathways.
PMID: 32350606 [PubMed - indexed for MEDLINE]

Source: Clinical Prostate Cancer - June 17, 2020 Category: Cancer & Oncology Authors: Abdelsalam RA, Khalifeh I, Box A, Kalantarian M, Ghosh S, Abou-Ouf H, Lotfi T, Shahait M, Palanisamy N, Bismar TA Tags: J Cancer Res Clin Oncol Source Type: research