9. Expansion of the CIViC data model for functional annotation of cancer variants

With clinical adoption of massively parallel sequencing into personalized cancer treatment, a bottleneck occurs during clinical interpretation of the large amount of variants seen in tumors, which requires curating an ever increasing pool of published studies. While some groups approach this problem by housing variant interpretations behind paywalls to support further curation, the Clinical Interpretations of Variants in Cancer database (CIViC, www.civicdb.org) employs crowdsourced curation and expert moderation within a fully open and free resource.

Source: Cancer Genetics and Cytogenetics - May 31, 2020 Category: Genetics & Stem Cells Authors: Arpad Danos, Kilannin Krysiak, Jason Saliba, Justin Guerra, Alex Wagner, Joshua McMichael, Susanna Kiwala, Adam Coffman, Erica Barnell, Nicholas Spies, Lana Sheta, Shahil Pema, Lynzey Kujan, Kaitlin Clark, Malachi Griffith, Obi Griffith Source Type: research