15. The good, the bad, and the ugly of SNP array testing for cutaneous melanocytic neoplasms

Cutaneous melanocytic neoplasms (CMNs) with ambiguous histologic features are diagnostically challenging for anatomic pathology practices. Ancillary genomic testing by SNP array can identify copy number abnormalities and allelic imbalances potentially associated with malignancy. We tested 445 formalin fixed, paraffin embedded CMNs by SNP array (OncoScan CNV Plus Assay, Thermo Fisher Scientific). Specimens were reviewed by a pathologist for acceptable amount and percentage of tumor cells. The reportable range included deletions> 1 megabase (Mb), duplications> 2 Mb, copy neutral loss of heterozygosity (cnLOH)> 10 Mb, or any detectable alteration affecting gene regions known to be associated with melanoma; benign alterations were excluded.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research