27. Genome imaging of head and neck solid tumors: Oropharyngeal, tongue, and thyroid cancers
Large structural variants (SVs), such as insertions, deletions, and translocations are not readily detected using standard methods of whole genome analysis. Genome imaging using the Saphyr instrument from Bionano Genomics detects large (>500bp) and complex SVs that are difficult to detect using traditional short read sequencing alone. We have isolated high-molecular weight DNA (>150,000 bp) from various solid head and neck tumors using a nanobind disc, consisting of novel nano structured silica surrounding a paramagnetic disk.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Brandon LaBarge, Max Hennessy, Lijun Zhang, Kathryn Sheldon, David Goldenberg, James Broach Source Type: research
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