Serum neurofilament light chain studies in neurological disorders, hints for interpretation

Neurofilaments are cylindric proteins located in the dendrites, soma, and in particular axons of neurons, where they confer structural stability, promote axonal growth, and allow intracellular transport. With a diameter of 10  nm, neurofilaments are classified as intermediate (i.e., larger than actin but smaller than myosin) filaments, and are heteropolymers composed by four different subunits based on the length of the carboxy-terminal region: neurofilament light chain (NfL), neurofilament middle chain (NfM), neurofil ament heavy chain (NfH), and alpha-internexin [1].
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research