Spiro Heterocyclic Compounds as Potential Anti-Alzheimer agents (Part 2): their Metal Chelation Capacity, POM Analyses and DFT Studies.

CONCLUSION: The screening of spirocompounds (1-6) against cholinesterases revealed that some of them show considerable potential to inhibit AChE and BChE. Herein we propose that the spiro molecules after further derivatization could serve interesting AD inhibitor drugs.
PMID: 32520690 [PubMed - as supplied by publisher]

Source: Medicinal Chemistry - June 9, 2020 Category: Chemistry Authors: Hadda TB, Deniz FSS, Orhan IE, Zgou H, Rauf A, Mabkhot YN, Bennani B, Emam DR, Kheder NA, Asayari A, Bin Muhsinah A, Maalik A Tags: Med Chem Source Type: research