Design and Synthesis of arylnaphthalene lignan lactones derivatives as Potent Topoisomerase Inhibitors.

CONCLUSION: This work indicates that arylnaphthalene lignan lactones derivatives represent a novel type of Topo IIα inhibitory scaffold for developing new antitumor chemotherapeutic agents. PMID: 32520691 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32520691?dopt=Abstract

Source: Medicinal Chemistry - June 9, 2020 Category: Chemistry Authors: Chen W, Feng Z, Hu D, Meng J Tags: Med Chem Source Type: research