daf-16 /FOXO and glod-4 /glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans

Conclusions/interpretation Human insulin and its analogues prevent the reduction in lifespan and neuronal damage caused by HG conditions. The effect of human insulin is mediated by a daf-2/insulin receptor and daf-16/FOXO-dependent pathway and is mediated by upregulation of detoxifying mechanisms.

http://link.springer.com/10.1007/s00125-014-3415-5

Source: Diabetologia - January 10, 2015 Category: Endocrinology Source Type: research