The Role of Radiotherapy for Chordoma Patients Managed With Surgery: Analysis of the National Cancer Database

Conclusion. Patients with positive surgical margins benefit from adjuvant RT. Optimal OS is associated with adjuvant RT administered with advanced techniques and cumulative dose more than 65 Gy. Level of Evidence: 4
Source: Spine - Category: Orthopaedics Tags: SURGERY Source Type: research

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Conclusion: We demonstrate that CDK9 expression in chordoma correlates with patient outcome, and, when inhibited, chordoma cell growth and proliferation significantly decreases. Taken together, these results support CDK9 as an emerging potential target in chordoma therapy.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
We present the respective correlation of brachyury expression with tumor progression, distant metastasis, survival rate and prognosis in several types of tumor samples (including chordoma, lung cancer, breast carcinoma, and prostate cancer), and various brachyury gain-of-function and loss-of-function experiments are summarized to explore its specific role in respective tumor cell line in vitro. In addition, we also discuss another two programs relating to brachyury function: epithelial-to-mesenchymal transition (EMT) and cell cycle control, both of which implicate in the regulation of brachyury on biological behavior of tu...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: The occurrence of young age at diagnosis, skull base presentation, or multiple primary chordomas should encourage careful review of family history for patients diagnosed with chordoma as well as screening of at-risk family members by MRI for early detection of chordoma. Furthermore, given genetic predisposition in some patients with familial chordoma, identification of a specific mutation in a family will permit surveillance to be limited to mutation carriers-and consideration should be given for imaging the entire neuraxis in any chordoma patient presenting at an early age or with a blood relative with chordo...
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
Abstract Chordoma is a rare bone cancer originating from embryologic notochordal remnants. Clival chordomas show different dural penetration ability, with serious dural penetration exhibiting poorer prognosis. The molecular mechanism of dural penetration is not clear. We analyzed lncRNA and mRNA profiles in 12 chordoma patients with different degrees of dural penetration using expression microarrays. The differentially expressed lncRNAs and mRNAs were used to construct a lncRNA-mRNA co-expression network. LncRNAs were classified into lincRNA, enhancer-like lncRNA, or antisense lncRNA. Biological functions for lncR...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
Conditions:   TNBC - Triple-Negative Breast Cancer;   Head and Neck Squamous Cell Carcinoma;   Squamous Cell Carcinoma of Anal Canal;   Uveal Melanoma;   Glioblastoma;   Colorectal Cancer;   Chordoma;   Squamous Cell Carcinoma of the Lung;   KRAS G12D;   KRAS G13D;   EGFR Amp lification;   Epithelial Ovarian Cancer;   Hepatocellular Carcinoma;   Anaplastic Thyroid Cancer;   Pancreas Cancer Intervention...
Source: - Category: Research Source Type: clinical trials
Study Design.. A meta-analysis. Objective.. The goal of this study was to accurately evaluate the risk ratio (RR) of recurrence in chordoma patients with wide margin after removing the tumors using surgery, compared with inadequate margin (intralesional or marginal). Summary of Background Data.. As a rare malignant bone cancer, the more effective treatment for sacral chordoma is still surgical resection. However, there is no convincing evidence and risk ratio about sacral chordoma patients would be benefit from which kind of surgical margin. Methods.. We searched the PubMed, Cochrane Library, Web of Science, and...
Source: Spine - Category: Orthopaedics Tags: LITERATURE REVIEW Source Type: research
Conditions:   Malignant Rhabdoid Tumor;   Rhabdoid Tumor of the Kidney;   Epithelioid Sarcoma;   Chordoma (Poorly Differentiated or De-differentiated);   Atypical Teratoid/Rhabdoid Tumor;   Other INI1 Negative Malignant Tumors (With PI Approval) Interventions:   Drug: Nivolumab;   Drug: Ipilimumab Sponsor:   Dana-Farber Cancer Institute Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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