How to Rapidly Determine First-in-Children Dosing for COVID-19 Therapeutics

Multiple drugs to treat coronavirus disease 2019 (COVID-19) are currently under investigation. As of May 1, 2020, ClinicalTrials.gov lists 409 active studies evaluating various therapeutics to treat COVID-19. Most of these studies enroll exclusively adults, providing limited data on children. However, if efficacy of COVID-19 therapeutics is established in adults, these drugs will also be widely prescribed to children for whom appropriate dosing has not been established. We know from observational studies across multiple therapeutics that inappropriate drug dosing places children at risk for treatment failure, toxicities, and even death.
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research