MiR-200c promotes proliferation of papillary thyroid cancer cells via Wnt/ β-catenin signaling pathway.

MiR-200c promotes proliferation of papillary thyroid cancer cells via Wnt/β-catenin signaling pathway. Eur Rev Med Pharmacol Sci. 2020 May;24(10):5512-5518 Authors: Ren ZF, Du MF, Fu H, Liu J, Xia FY, Du HN, Liu N Abstract OBJECTIVE: To investigate the potential effects of miR-200c on proliferation and apoptosis of papillary thyroid cancer (PTC) cells. MATERIALS AND METHODS: Micro ribonucleic acid-200c (miR-200c) inhibitor was transfected to down-regulate miR-200c expression. Cell counting kit-8 (CCK-8), colony formation experiment, and flow cytometry were used to detect the effects of miR-200c knockdown on proliferation and apoptosis of Butylated Hydroxytoluene 101 (BHT101) cells. The dual-luciferase reporter gene assay was conducted to detect whether miR-200c directly binds to the target gene. After knocking down miR-200c, quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting analysis were performed to detect changes of target genes regarding messenger RNA (mRNA) and protein. Western blotting analysis was also adopted to detect gene expression of Wnt/β-catenin signaling pathway-related proteins. RESULTS: Compared with those in control group, the proliferation and clone formation ability of BHT101 cells in miR-200c knockdown group were significantly inhibited (p
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

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ConclusionsRefined cut-offs for bCT and casCT in patients with nodular goiter are reported. Sensitive bCT was shown to have a high accuracy, but the combination with casCT data was needed to identify all MTC cases. The reliability and safety of calcium test strongly favour the routine use of CT determination in nodular thyroid disease.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Conditions:   Cardiovascular Disorder;   Chronic Kidney Disease;   Metastatic Renal Cell Carcinoma;   Metastatic Thyroid Gland Medullary Carcinoma;   Stage IV Renal Cell Cancer AJCC v8;   Stage IV Thyroid Gland Medullary Carcinoma AJCC v8;   Stage IVA Thyroid Gland Medullary Carcinoma AJ CC v8;   Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8;   Stage IVC Thyroid Gland Medullary Carcinoma AJCC v8 Interventions:   Other: Best Practice;   Other: Blood Pressure Me...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, a potential international multicenter study of female patients undergoing RAI of DTC as children, adolescents, or young adults, with a sufficient sample size, is feasible. However, breast cancer screening of a larger cohort of DTC patients is not unproblematic for ethical reasons, due to the likely, at most slightly, increased risk of breast cancer post-RAI and the expected ~10% false-positivity rate which potentially produced substantial “misdiagnosis.”
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
CONCLUSIONS: The expression of linc00324 is significantly increased in PTC tissues and cells. Silencing linc00324 may inhibit the proliferation of PTC cells, arrest the cell cycle in G1/G0 phase, and promote the apoptosis by inhibiting the Notch signaling pathway. PMID: 32633374 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: We demonstrated the involvement of PTK7in the progression of thyroid cancer, and therefore provided a novel and promising therapeutic target for thyroid cancer treatment. PMID: 32633373 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Conditions:   Thyroid Nodules;   Thyroid Cancer Interventions:   Behavioral: Counseling using the electronic conversation aid;   Behavioral: counseling by routine care Sponsors:   University of Florida;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article discusses the accumulating data on various malignancies described in primary Sjögren syndrome, highlighting non-Hodgkin lymphoma and thyroid, multiple myeloma, and skin cancers. These reported associations may have clinical implications in daily practice and contribute to understanding of both autoimmunity and cancer. PMID: 32631601 [PubMed - in process]
Source: Clinical Lymphoma and Myeloma - Category: Cancer & Oncology Authors: Tags: Rheum Dis Clin North Am Source Type: research
In this study, we describe anaplastic thyroid cancer in a 46-year-old woman with TD who had two germline thyroglobulin (TG) gene mutation, c.3790T>C (p, Cys1264Arg) in exon 17 and a novel c.7070T>C (p.Leu2357Pro) in exon 41 of the TG gene. Two affected younger sisters were also found to have the same TG mutation but not anaplastic thyroid cancer. Any thyroid nodular lesions that develop in patients with TD should be investigated carefully. PMID: 32633627 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
The incidence of thyroid cancer is increasing worldwide. This is not accompanied by a corresponding increase in mortality. In contrast, in most populations ’ thyroid cancer mortality has been decreasing in rece...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Correspondence Source Type: research
Thyroid lobectomy is performed for symptomatic benign nodules, indeterminate nodules, or low-risk well differentiated thyroid cancer. We aimed to determine factors associated with thyroid stimulating hormone over goal (TH) following lobectomy.
Source: American Journal of Surgery - Category: Surgery Authors: Source Type: research
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