Pyrazole derivatives of medically relevant phenolic acids: insight into antioxidative and anti-LOX activity.

CONCLUSION: In this research, protocatechuic and vanillic acid pyrazole derivatives have been obtained for the first time. In vitro antioxidative assay suggests that pyrazole derivate of protocatechuic acid is a powerful radical scavenger, while anti-LOX assay indicates a pyrazole derivative with 4-hydroxyphenyl moiety.
PMID: 32484771 [PubMed - as supplied by publisher]

Source: Medicinal Chemistry - June 1, 2020 Category: Chemistry Authors: Milovanović V, Petrović ZD, Novaković S, Bogdanović GA, Simijonović D, Mladenović M, Branković J, Petrović VP Tags: Med Chem Source Type: research