Opioid receptors beyond pain control: The role in cancer pathology and the debated importance of their pharmacological modulation

Publication date: Available online 3 June 2020Source: Pharmacological ResearchAuthor(s): Marco Carli, Sandra Donnini, Carolina Pellegrini, Erika Coppi, Guido Bocci
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research

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This study is aimed to explore the role of a stable perfusion temperature in promoting bowel recovery of PC patients due to gastrointestinal malignancies. METHODS: Between January 2012 and July 2013, 59 PC patients undergoing cytoreductive surgery and three-cycle HIPEC were included. Patients having stable perfusion temperature for all cycles were assigned into the study group, with the rest having unstable temperature into the control group. Time of flatus and defecation passage and initiation time of enteral nutrition were compared between both groups to detect the significance in bowel function recovery, with visua...
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Tags: Cancer Biol Ther Source Type: research
BOWEL cancer symptoms include weight loss, stomach pain, and feeling very tired for no obvious reason. But you could also be at risk of the disease if you notice small changes to your daily toilet routine. How often do you use the bathroom? These are the bowel cancer signs in your poo.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusion: When assigning breast cancer survivors to an exercise program, the preferential or predominant activity should include strength exercises. On the other hand, as the second choice, those patients with particularly low levels of Vitality or Physical Limitations will show greater improvement with an aqua fitness program.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Source: CDC Preventing Chronic Disease - Category: International Medicine & Public Health Tags: Public Health Source Type: news
CONCLUSIONS: In selected cases, MISS surgeries may be considered as a valid alternative to open surgery. Although the efficacy of PPSF has been well documented in trauma or degenerative spine surgery, there is not sufficient literature about MISS techniques in spinal metastasis and further studies are needed to elucidate the most appropriate patient in which this approach could represent the gold standard of treatment. PMID: 32633339 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
BACK PAIN is so prevalent in the UK, it's likely you know someone who suffers from an achy back - the person might even be you. But here are the signs it could be indicative of spinal cancer.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
In this study, we aimed to assess the reliability and validity of the newly developed Japanese version of th...
Source: BMC Palliative Care - Category: Palliative Care Authors: Tags: Research article Source Type: research
ConclusionTapentadol is effective and well tolerated in opioid-na ïve and opioid-tolerant patients with cancer pain of varying pathophysiology, including those with nociceptive and/or neuropathic components. Tapentadol may be considered for first-line use in moderate-to-severe cancer-related pain.
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research
ConclusionPET/CT imaging has an established role in the diagnosis of some urological malignancies and, in specific clinical indications, is used because of the enormous potential to alter patient management. Besides the established roles of FDG PET/CT, the advances of novel radiotracers for PET/CT imaging in urological malignancies, such as PSMA PET/CT, allows evaluation in the settings of staging, recurrence, response to therapy, and prognosis. Furthermore, PET/CT imaging helps in planning and assessing response to treatment in theranostics. Molecular images identify early changes that conventional anatomical studies cann...
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research
This is a review of the evidence from studies of the efficacy and tolerability of topically applied, high-concentration (8%) capsaicin in Chemotherapy-induced peripheral neuropathy (CIPN). Methods: For this review, we searched EMBASE and MEDLINE to 14 April 2020. The terms used in the search included capsaicin patch, chemotherapy-induced peripheral neuropathy, cancer pain or malignant pain. Results: A total of 69 studies were obtained but only 5 were selected for the final analysis. Capsaicin 8% patch provides significant pain relief in CIPN, and may lead to regeneration and restoration of sensory nerve fibers.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
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