GSE141209 Analysis of Retinoblastoma Transcriptome

Contributors : Diana E Alvarez-Suarez ; Martha V Ponce-Casta ñeda ; Hugo A Tovar-Romero ; Enrique Hernandez-LemusSeries Type : Expression profiling by arrayOrganism : Homo sapiensIn this data, we examined Transcriptome detection and expression in 8 samples of Retinoblastoma. We found a central core shared by all samples .We used exon arrays to find a detected and undetected transcripts and genes in Retinoblastoma and we compared unilateral and bilateral samples.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

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CONCLUSIONS: Intra-arterial chemotherapy in patients weighing ≤10 kg is a safe and effective treatment.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: PEDIATRICS Source Type: research
Publication date: Available online 10 July 2020Source: Cancer EpidemiologyAuthor(s): K. Waddell, M. Matua, C. Bidwell, R. Atwine, J. Onyango, S.V. Picton, I. Simmons, J. Stahlschmidt, W.T. Johnston, R. Newton
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS miR-512-3p improved the DDP resistance of RB cells by promoting ERS-induced apoptosis and inhibiting the proliferation and autophagy of RB cells. PMID: 32641679 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Researches validate that circular RNAs (circRNAs) are dysregulated in a variety of malignancies and play an important role in regulating the malignant phenotype of tumor cells. Nevertheless, the role of circ_0...
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Tags: Primary research Source Type: research
We are thankful for the opportunity to respond to the issues raised in Dr Brown's letter. We would also like to thank Dr Brown for these comments and for expressing interest in our work.1
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Correspondence Source Type: research
AbstractObjectiveTo explore the mechanisms underlying the proliferative inhibition of Chinese herbal medicine Kang-ai injection (KAI, 康艾注射液) in gastric cancer cells.MethodsGastric cancer cell lines MGC803 and BGC823 were treated by 0, 0.3%, 1%, 3% and 10% KAI for 24, 48 and 72 h, respectively. The cell proliferation was evaluated by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay. The apoptosis and cell cycle were evaluated by flow cytometry. Interleukin (IL)-6 mRNA and protein expression levels were detected by quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-li...
Source: Chinese Journal of Integrative Medicine - Category: Internal Medicine Source Type: research
Abstract Renal cell carcinoma (RCC) is the most aggressive type of genitourinary cancer and is resistant to current therapies. Identifying drugs that enhance the efficacy of RCC standard-of-care drugs at sublethal concentrations is an alternative therapeutic strategy. Ribociclib is an orally available cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor that is approved for the treatment of breast cancer. In this work, we demonstrate that ribociclib at clinically achievable concentrations inhibits proliferation of 7 out of 9 tested RCC cell lines, with IC50 range from 76 to 280 nM. In addition, ribociclib ind...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
In conclusion, telmisartan suppressed the proliferation of human gastric cancer cells by inducing cell cycle arrest. PMID: 32627043 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
MicroRNA‑34a inhibits the proliferation and promotes the chemosensitivity of retinoblastoma cells by downregulating Notch1 expression. Mol Med Rep. 2020 Jun 15;: Authors: Yin W, Gao F, Zhang S Abstract MicroRNAs (miRs) are potential therapeutic targets for tumors. The aims of the present study were to investigate the regulatory effects of miR‑34a on the proliferation, apoptosis and chemosensitivity of retinoblastoma (RB) cells, and to identify the possible underlying mechanism involving Notch1. It was found that miR‑34a was downregulated, and Notch1 was upregulated in HXO‑RB44 and Y79 cells. In...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Gangliosides are carbohydrate-containing sphingolipids that are widely expressed in normal tissues, making most subtypes unsuitable as targets for cancer therapy. However, the disialoganglioside GD2 subtype has limited expression in normal tissues but is overexpressed across a wide range of tumors. Disialoganglioside GD2 can be considered a tumor-associated antigen and well-suited as a target for cancer therapy. Disialoganglioside GD2 is implicated in tumor development and malignant phenotypes through enhanced cell proliferation, motility, migration, adhesion, and invasion, depending on the tumor type. This provides a rati...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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