Autism-associated synaptic mutations impact the gut-brain axis in mice

Publication date: Available online 30 May 2020Source: Brain, Behavior, and ImmunityAuthor(s): Chalystha Yie Qin Lee, Ashley E. Franks, Elisa L. Hill-Yardin
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research

Related Links:

CONCLUSIONS: The concurrent assessment of insistence on sameness behaviour and anxiety in ASD may help in understanding current symptom profiles and anticipating future trajectories. High preschool insistence on sameness in particular may be associated with elevated current or future anxiety symptoms. PMID: 32641181 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
By using a nationally representative school-based sample (4,816 children aged 8-14  years), we examined the risk of suicidality in children with elevated autistic traits and assessed the mediation of anxiety/depression and moderation effects of family fun...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Publication date: Available online 8 July 2020Source: NeuroImage: ClinicalAuthor(s): Christopher J. Hyatt, Vince D. Calhoun, Brian Pittman, Silvia Corbera, Morris D. Bell, Liron Rabany, Kevin Pelphrey, Godfrey D. Pearlson, Michal Assaf
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
AbstractAutism spectrum disorder (ASD) is a genetic neurodevelopmental disorder involving multiple genes that occurs in early childhood, and a number of risk genes have been reported in previous studies. However, the molecular mechanism of the polygenic regulation leading to pathological changes in ASD remains unclear. First, we identified 8 dysregulated gene coexpression modules by analyzing blood transcriptome data from 96 children with ASD and 42 controls. These modules are rich in ASD risk genes and function related to metabolism, immunity, neurodevelopment, and signaling. The regulatory factors of each module includin...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
AbstractWhen parents and teachers align their practices across home and school, it may optimize services for children with autism spectrum disorder (ASD).Partners in School is a multi-faceted implementation strategy designed to improve ASD services in schools. The goal is to increase parents ’ and teachers’ use of evidence-based practices (EBPs) and to align those EBPs across settings. We pilotedPartners in School with 49 parent –teacher dyads to assess administration and the factors associated with reported fidelity to the model. Specifically, we measured the number of intervention steps both parents and...
Source: Administration and Policy in Mental Health and Mental Health Services Research - Category: Psychiatry Source Type: research
This study aimed to investigate the representation of gender and sexual diversity within autistic females and examine their rates of regretted, and unwanted, sexual encounters among females with a transgender gender identity and non-heterosexual sexual orientation.MethodsTwo hundred and ninety-five females completed the Sexual Behaviour Scale-III (SBS-III) online. Self-reported gender identity and sexual orientation were compared between 134 autistic (Mage= 26.2  years, SD= 8.7) and 161 non-autistic females (Mage = 22.0  years, SD = 4.6). Differences in the prevalence of negative sexual experiences were compa...
Source: Molecular Autism - Category: Molecular Biology Source Type: research
Publication date: Available online 9 July 2020Source: Journal of Neuroscience MethodsAuthor(s): Yufei Wang, Jianxin Wang, Fang-Xiang Wu, Rahmatjan Hayrat, Jin Liu
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
(Istituto Italiano di Tecnologia - IIT) Researchers at IIT-Istituto Italiano di Tecnologia discovered a novel chemical compound, which has the potential to became a new drug for the treatment of core symptoms of brain disorders like Down syndrome and autism. Results are obtained in preclinical models where the new compound ameliorated difficulties in cognitive tasks, social interactions and repetitive behaviors. Researchers aim to create a start-up company in order to further develop this compound and make it a treatment for patients
Source: EurekAlert! - Biology - Category: Biology Source Type: news
In this study, the brain basis of sentence context effects on word understanding during reading was examined in autism spectrum disorder (ASD) and typical development (TD) using magnetoencephalography. The correlates of a history of developmental language delay in ASD were also investigated. Event related field responses at early (150 ms after the onset of a final word) and N400 latencies are reported for three different types of sentence final words: dominant homonyms, subordinate homonyms, and unambiguous words. Clear evidence for semantic access was found at both early and conventional N400 latencies in both TD particip...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Conclusions: Findings add to the field of speech therapy by providing awareness of the challenges experienced by these mothers as well as those that are unique to the South African context. In addition, the current study provides insight into the experiences of mothers from different contexts and cultural backgrounds to those reported in previous literature.Folia Phoniatr Logop
Source: Folia Phoniatrica et Logopaedica - Category: Speech-Language Pathology Source Type: research
More News: Autism | Brain | Neurology