Digital spatial profiling application in breast cancer: a user ’s perspective

We present the application of this technology to breast cancer samples. Applying the ‘off the shelf’ cancer panel and a custom-conjugated E-cadher in antibody, we quantify vast intra-tumoural heterogeneity in immunological and tumour markers, and demonstrate a need for focussed selection of target cell populations. The technology offers enormous potential not only for making research advances but also for improving standard operating procedure s in diagnostic applications.
Source: Virchows Archiv - Category: Pathology Source Type: research