Late effects of adjuvant chemotherapy adumbrate dormancy complexity in breast cancer.

CONCLUSIONS: Present results reveal the ability of adjuvant chemotherapy to reduce not only the rate of early relapses, but also the rate of intermediate relapses at about the sixth year of follow up. Adjuvant chemotherapy is not impacting on the development of metastases underlying the late peak detected at the tenth year. These findings suggest the existence of a previously unknown dormancy state that, at the primary tumour surgical removal, results in evolving chemo-sensitive metastatic processes, and, moreover, of a later chemo-refractory dormancy state.
PMID: 32428688 [PubMed - as supplied by publisher]

Source: Breast - May 7, 2020 Category: Cancer & Oncology Authors: Demicheli R, Desmedt C, Retsky M, Sotiriou C, Piccart M, Biganzoli E Tags: Breast Source Type: research