Offspring outcomes when a parent experiences one or more major psychiatric disorder(s): a clinical review

We sought evidence on quantifiable offspring outcomes, including problems, needs and strengths, associated with their experience of major parental psychiatric disorder(s), focusing on schizophrenia, affective illnesses and personality disorder(s). We were motivated by the absence of any systematic exploration of the needs of offspring of parents in secure hospitals. Seven electronic databases were searched to identify systematic reviews of studies quantifying offspring outcomes when a parent, or parent surrogate, has major psychiatric disorder(s). Our search (updated in February 2018) identified seven high-quality reviews, which incorporated 291 unique papers, published in 1974 –2017. The weight of evidence is of increased risk of poor offspring outcomes, including psychiatric disorder and/or behavioural, emotional, cognitive or social difficulties. No review explored child strengths. Potential moderators and mediators examined included aspects of parental disorder (eg, severity), parent and child gender and age, parenting behaviours, and family functioning. This clinical review is the first review of systematic reviews to focus on quantifiable offspring problems, needs or strengths when a parent has major psychiatric disorder(s). It narratively synthesises finding s, emphasising the increased risk of offspring problems, while highlighting limits to what is known, especially the extent to which any increased risk of childhood problems endures and the extent to which asp...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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In this study, we investigate the effect of clozapine on MK-801-induced neurochemical and neurobehavioral alterations in the prefrontal cortex of mice. Acute administration of NMDA noncompetitive antagonist MK-801 impairs motor coordination, grip strength, and locomotor activity. Clozapine is the only medication that is indicated for treating refractory schizophrenia, due to its superior efficacy among all antipsychotic agents; however, its mechanism is not well understood. To understand its mechanism, we investigated the effects of clozapine on motor coordination, locomotor activity, and grip strength in mice against the ...
Source: Journal of Environmental Pathology, Toxicology and Oncology - Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research
CONCLUSION: For the majority of the physicians surveyed, psychiatry represented a public health priority, and their prioritising provides a probable explanation for their positive perception of their role in the management of mental disorders. However, we went on to observe that a number of difficulties constituted obstacles to their role in management of mental disorders and induced them to refer their patients to psychiatrists. Our analysis highlighted the impact of continuing education on physicians' attitudes and the interest of collaboration between practitioners. Efforts in university teaching and continuous educatio...
Source: Revue d Epidemiologie et de Sante Publique - Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research
Condition:   Schizophrenia Intervention:   Other: treatment-as-usual plus aerobic walking Sponsors:   Chang Gung Memorial Hospital;   Ministry of Science and Technology, Taiwan Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   The Impact of Stigma on the Quality of Life of People With Schizophrenic Disorders and Their Siblings Intervention:   Sponsor:   Januel Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Schizophrenia Intervention:   Other: treatment-as-usual plus aerobic walking Sponsors:   Chang Gung Memorial Hospital;   Ministry of Science and Technology, Taiwan Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   The Impact of Stigma on the Quality of Life of People With Schizophrenic Disorders and Their Siblings Intervention:   Sponsor:   Januel Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
As an integrator of molecular pathways, mTOR has been associated with diseases including neurodevelopmental, psychiatric and neurodegenerative disorders as autism, schizophrenia, and Huntington ’s disease. An important brain area involved in all these diseases is the striatum. However, the mechanisms behind how mTOR is involved in striatal physiology and its relative role in distinct neuronal populations in these striatal-related diseases still remain to be clarified.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Archival Report Source Type: research
The advent and application of high-throughput sequencing is revolutionizing our understanding of the molecular neurobiology of diverse psychiatric disorders. Whole-genome sequencing, which targets the coding regions of the genome, and whole-exome sequencing are being applied to study multiple psychiatric disorders, including autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder, schizophrenia, and Tourette ’s disorder, among others [(1–3); https://schema.broadinstitute.org]. These studies have demonstrated a role for ultrarare, deleterious, frequently de novo variation in each disorder, and h...
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Low levels of vitamin D are prevalent among patients with schizophrenia and have been linked to the risk and outcome of the disorder. Vitamin D has a regulatory effect on the inflammatory system, which is dysfunctional in schizophrenia. We investigated the association between serum vitamin D levels, inflammatory status, and severity of schizophrenia symptoms. A total of 39 clozapine-treated schizophrenia patients were recruited to the study. Blood samples for biochemical analysis were collected from all participants. Serum levels of vitamin D and cytokines (IL-4, IL-6, IL-10, and TNF-α) were analyzed and the associat...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Original Articles Source Type: research
This study, based on the ‘Servizi Territoriali Associati per la Ricerca’ (STAR) Network Depot Study nationwide baseline data, explored whether individual symptoms severity and clusters might influence the prescription of paliperidone palmitate 1-month (PP1M) vs. aripiprazole monohydrate. The Brief Psychiatric Rating Scale (BPRS) was used to assess psychopathology and relevant symptoms clusters. Drug Attitude Inventory, 10 items, was used to test attitude towards medications. Adherence to treatments was rated according to the Kemp seven-point scale. We assessed for eligibility 451 individuals and, among them, we...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Original Articles Source Type: research
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